Mice problems

I have three Toyotas. A 97 Carolla, a 01 Tacoma, and an 07 Yaris. Both the Carolla and the Tacoma have been damaged by mice getting into the heating/AC passages. A few days ago a mouse got into the passenger compartment of the Yaris and made confetti of a roll of paper towels. The doors were closed and the windows up. How could that happen? I think the mice got into the others through the drains on the outside air intake. I can’t see any other way. The cleanup is a real problem. Any suggestions are welcome. I live in the forest. I can’t kill all of the mice in the woods.