Sputtering Truck

I have a 2000 Ford Expedition 5.4L, 4WD. It began to sputter so I changed the air filter and fuel filter. Took it for a test drive and it is still sputtering. What could it be; bad gas, blown fuse or what? What are some remedies I could try.

Thanks Heath

Check for a vacuum leak.

Possibly at the air plenum, hoses, or air intake connections to the throttle body.

Check for continuous spark too.

How old are the plugs & wires?