It’s not San Francisco unless they somehow filled in the Bay. It is probably San Jose, given the Redwood City license plate frame. The photo would probably have been taken up on Skyine, looking east across San Jose.
For anyone coming to the Bay Area who wants a great scenic drive, I highly recomend Skyline, which runs from the mountains south of San Jose along the top of the hills up towards San Mateo, where you have to come down on Hwy 92. It’s utterly gorgeous up there with great views of the bay and more limited views of the ocean, and is a great driver’s road without much traffic (except for motorcycles).
A favorite drive on a day when it is sunny at the coast is to take Hwy 1 down the coast to just short of Santa Cruz, cut north through the mountains via Big Basin State Park (some of the best redwood groves around), then take Skyline and I280 back to the city. I’ve done that trip dozens of times and never tire of it. You get cliffs, farms, beaches, redwoods, panoramic city views, even wineries in the Santa Cruz Mountains. The only thing missing is a bridge. On a busy Sunday I’m perfectly happy not having to sit in traffic trying to get home across the Bay Bridge.