06 Toyota Sienna

All the electrical controls on the steering wheel stopped working (radio controls, cruise control, horn) please help

Check the fuses, then look for a loose, disconnected, or damaged wiring connection going to the steering column.

The clock spring behind the steering wheel has probably failed. The clock spring is what allows the electrical connection on the steering wheel by reeling out a wire ribbon as the steering wheel is turned. Sorta works like how a tape measure works.