Raise car with neoprene spacers

Will I have to realign my car if I put 2" inch rubber spacers in my springs?

I would expect some issues adding two inches. I certainly would do a realignment.

Yes, absolutely. You’ll move the wheels up out of their normal vertical attitude and into an area where they’ll be leaning. Camber angle is designed to control the track of a vehicle as its suspension moves through its travel. You’ll be messing this up.

You’ll also creat more wear on the CV joints and all other articulated drivetrain joints. The more of an engine you put articulating spinning joints in, the faster they wear. The includes U-joints and CV joints.