High pitch sustained whistling noise at 65mph plus

when operating at over 65mph a high pitch whistling noise appears, tried openning and closing windows and roof no change ?? seems air is entering vehicle, tried putting on rain deflectors on doors, all rubber seals seem intact, still got noise

Has the windshield on the car ever been replaced?
I have seen this phenomenon on cars with poorly-sealed windshields.

Have you tried removing the radio antenna? My van has a distinct whistle at highway speeds, and it is the antenna that is the culprit. Sometimes just knowing what it is gives you piece of mind.