I’m a little concerned this problem might be engine pinging. That means the gas inside the cylinder is exploding before it reaches the point in the cycle it should. It’s noticed on rapid acceleration, going up hills, and often not at idle or just going down a level road at a constant speed. Severe pinging can damage the engine internals if it goes on for any length of time. Severe pinging sounds like you are shaking a metal can with coins inside. Does this sound anything like that? If so you need to take your Honda to a mechanic immediately. Minor pinging can sound like that too, but it is usually much more subtle, often you can hear the individual “ping” sounds, very faintly. Minor pinging needs to be addressed asap, but isn’t a dire emergency like severe pinging.
Has anything happened to the engine recently, like work done on it? Any gas fill ups from stations you don’t normally use? Is the check engine light on?