Let There Be Light (Please!) Sienna Dome Fuse

Looking at some data for the dome light circuit power it shows the power going to a lot more things than just the dome light so my previous suggestion to fix the trouble isn’t real good. The dome light fuse in the panel under the hood ties to a junction point in the dash fuse panel. Connection point C27 of the panel ties fused power to 3 other points in the dash panel, they are P16, R6, and L13. These 3 points tie to a number of places for the door lights, roof lights, and vanity lights. To me, this is the most logical point to start the hunt for the trouble. By removing two of the legs one will be left on line to see if the fuse still blows out. If that works ok after enough time has gone by then add another leg and see if that works ok. If that works ok then by process of elimination the trouble must be on the final leg not connected on line.

P16 ties to the luggage area and left slide door.
R6 ties to the interior lights and vanity lights.
L13 ties to the right slide door and other points.

After the correct leg with the trouble on it has been determined it will be a lot easier to pin down the problem area since a lot of possible areas of trouble will have been eliminated. Like Barkydog suggested, the doors are good suspects since they can stress the wires when they open and close.

One thing you could do is purchase a 10 amp circuit breaker and add some leads on it so it could replace the dome fuse until you find the trouble and fix it. The breaker will reset itself after the intermittent short is removed and you will have lights again. I wouldn’t make that a permanent fix though.