In December 1964, I put a rebuilt motor and transmission in my 1953 Chevrolet and drove it around for a few days.
Then, one day at noon, I took off and 50 hours later, had driven 2050 miles to Ft. Lewis Washington.
As I crossed the mountains, there was a major blizzard. Every time I pulled in for gas, the attendants looked surprised. All night long, they kept shutting the highway down behind me.
I am bored with long trips now, but for a long time I would leave my house in McAllen ,and spend the night 700 miles away. Until I got the 2002 Sienna, it was in an 1989 Dodge Caravan, or something even older. (Never again.)
My SIL thinks a trip to San Antonio is transpolar. His wife, whom I taught to drive, views San Antonio as her first restroom break.
Traditionally, most highway breakdowns involved belts; hoses; and tires, period. Today, add oil and coolant levels. check those things out and go as recommended.
Don’t forget food for yourself, and water for at least one day if you are going in hot country.