2016 Mercedes-Benz GL-Class - Misfires

engine light cylinders 1 and 4 misfire

I am guessing you are asking a question on those 2 cylinders misfiring and not just venting. you can try this to see if it is your coils on those 2 cylinders. obviously, you would switch the 2 coils on your car that you are getting the misfires on and see if they move.

Fix Misfire on Mercedes | Misfiring Cylinder Check Engine Light | CarMAN - YouTube