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I have a 2005 Acura MDX with 132,000miles. At 58-64miles an hr. there is a high pitch whining noise. The Acura dealer tells me the bearing on the drive shaft needs replacing at a cost of $1000. My question is it safe to drive wihout replacing the assembly and is the cost resonable?

For a dealer the price is likely on par. If you question it I would seek out an indepedent and possibly independent Honda specialist for 2nd opinion and cost estimate. Dealers are top dollar for repairs.