If my AC works fine at the start of the drive, and then doesn't work at all, could it be low on refrigerant?

Maintenance/Repairs
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6

Go the relay route FIRST. Swap out your horn relay with the AC clutch relay. That worked for me on my 2003 Odyssey when my my AC would not cycle to the real cold air! My relay cost under $10. Easiest DIY vehicle repair out there 2007 Honda Odyssey is the most PRACTICAL vehicle on the road! Good luck.