2007 Dodge Ram 1500 “spludder” sound

My truck have a spludder sound to it while cruising and accelerating. No lost of power while cruising just a change in tone for a hot miniute.and then spludder sound. Something like a spark plugs not firing!???

Which engine? If the 5.7 L engine when transitioning from acceleration to cruise you may notice when the cylinder deactivation occurs.