Have the vehicle inspected thoroughly (brakes, steering and suspension, tires, alignment–checked and corrected if needed, etc etc) before the long trip…
As someone that worked at a shop right off 2 interstates (I65/I40) and close to another (I24) for many years, I have seen hundreds maybe thousands of out of towners passing through breaking down from this that or the other…
Lots of I thought my tires, or brakes, or ball joints, or whatever were good, and wasn’t…
Only you can know how many hours on the road you can handle. There was a time when I could have made that in a day and a half. Now it is 2 full days at least.