Seized driver's side door lock and latch

The driver’s side door won’t open! When I got in this morning (all doors unlocked), the door wouldn’t latch closed! Now it won’t open! The inside door latch is stuck in the ‘open’ position. Cannot lock or unlock the door with the key from the outside or manually from the inside or with the main electric locking mechanism panel. All other doors freely lock and unlock in all ways. The entire thing seems seized. What to do?