Assuming you did it properly, (e.g: plug off the vacuum line and create a road draft tube for the pcv port), then you’d see no short term difference. It has no effect on engine performance or fuel mileage.
However, it’s the longer term that is more concerning. Without a functioning PCV valve, moisture will accumulate in the crankcase. That will reduce the life of your engine oil and will accelerate the formation of damaging sludge.
Depending on where you live, disconnecting the PCV may be illegal, for environmental reasons. It is illegal in the USA.
I’m curious about your motivation for doing this. I agree that some PCV valves are a big pain to access. But other than that, there is little to no downside for maintaining a functioning PCV.