Chevy Misfires

I have a 2000 Chevy Silverado 1500 4.8 liter with 96,000 miles. I have severe misfires on cylinders 1, 3, 5. I have replaced all wires and plugs and replaced the ignition coils on 1, 3, 5. I still have problems getting the engine to fire (it turns over fine) and when it is running I get several hundred to several thousand misfires on those cylinders. Any idea what else could be wrong?

I do not know, but I will bump this post into recent discussion where your post will get more looks

I would look for a wiring problem look as much as you can . then go to shop.