Big bucks if Prius runs out of gas

My dad told me about a friend of his who owns a Prius. He ran out of gas, after adding gas the car would not start, had to be towed to the dealership and then cost several hundred dollars to re-set or reprogram before the car would run. I bought a 2010 Prius for my wife, so Im wondering if this could be true. She panics if the gas gage gets below ? and has never run out of gas in her life, but Im curious if there is an issue if the gas was to run out. THANKS