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2004 Honda Pilot - cylinder 1 misfire

Cylinder 1 misfire detected

First thing I check on a single cylinder misfire is sufficient spark to and through the spark plugs. Then I check compression. If you do not have the proper diagnostic tools or expertise, and the spark plugs are due for changing, it wouldn’t hurt to just change the plugs. If they are due, you aren’t throwing money away unless you have bad compression. Or you could bring it somewhere to have it diagnosed. They will probably start by checking plugs and coils. If you think you can do it yourself, you can do plug and coil swaps to isolate which one is faulty. Let us know which direction you want to go.