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2002 Mazda 626- Codes and misfires

my cars check engine light came on out of the blue. put a code reader on it came up third cylinder misfire. drove down the road and noticed the check engine light went off. one week later my husband drove it and when i got into drive the next day the light was back on. code reader comes up with misfire cylinder 3. husband replaced plugs but nothing else so far. we were hoping changing plugs would fix problem. I need to smog my vehicle and now cant until fixed. any suggestions?

Could be a number of causes that may require a more in depth diagnosis. Start with a compression test of all cylinders.

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