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2000 Chevy blazer cylinder misfire

I have a 2000 Chevy blazer 4.3L 4 wheel drive. 4 of the 6 cylinders are misfiring and the car has completely lost power. Before this issue occurred it was running fine and the next morning when I went to start it the car was turning over and wouldn’t start. My dad and uncle believe it’s a distributor or computer issue but I would like other opinions about this issue

I presume you’ve had the diagnostic codes read since you know how many cylinders are misfiring. Suggest you post all the code numbers here, and I expect some good ideas on what might be wrong will show up shortly.

@Kgriffin‌

Have you hooked up a fuel pressure gauge?

Not all misfires are ignition related, and your “spider” fuel injection system has been known to be temperamental

Have you hooked up a spark tester yet?

As a matter of fact, that’s the very first thing I’d do, after posting those fault codes

On some GM distributors, the drive gear goes flat . . . without warning . . . and then you’re dead in the water

Fuel spider would be my guess. Here is a link to troubleshoot your problem.
http://troubleshootmyvehicle.com/gm/4.3L-5.0L-5.7L/how-to-trobleshoot-a-hard-to-diagnose-misfire-1