After reading all the posts, my answer is you are doing about all you can do.
The best way to get the highest mpg from your truck is to replace the plugs at least as often as recommended by Ford. Not any fancy plug just the correct plug that matches what came from the factory.
Change your air filter at or before the mfg recommended interval.
Pay attention to the tires you put on the car, go for tires with the least rolling resistance sized properly. Michelin and Goodyear are now advertising tires to improve fuel economy.
Keep you tire pressures at or just slightly above the recommendations on the sticker on the door jam or gas filler. Don’t overinflate the tires too much, this can just make the vehicle less safe in emergency handling.
Finally, coast when possible, and reduce your highway speeds from 70 or 75 mph, down to 60 to 65. You’ll take a bit longer to arrive, but save about 10% of your fuel just by backing off the speed during the trip.
The money you spend maintaining your vehicle will pay off in better mpg. The money you spend on aftermarket gizmo’s will likely not improve you mpg much if at all and will not recoup the money you spent on them.
When I got my '01 Toyota Sequoia just over a year ago the fuel computer showed 14 mpg as the average. I went through the vehicle bringing all the maintenance up to date, timing belt, fluids, air filter, etc. I changed the plugs myself and found the plugs in the vehicle had very worn electrodes. The truck had just under 90K miles and these plugs were either the original, or perhaps had been in there since 30K service.
With the new air filter and new plugs the mpg immediately improved from the 14 mpg up to 18 mpg in average mixed highway/city driving. This is a big truck with a V8 so I’m pretty pleased with this kind of mpg from it. I have other cars to drive when mpg is important. But I can’t get a load of stuff from Home Depot in the Civic, and it won’t pull the horse trailer either. Sometimes you just need a truck, so keep it maintained and drive it easy to max out your mpg.