My son started having issues with his late 90’s Astro at about 130 K miles. He ended up having a rebuild done on auto trans and engine within eight months of each event. This vehicle was purchased in a very used condition, so I could only assume that it was taken care of all that well previously. I have also heard of others getting 200+K miles on theirs, with few issues. He also had several interior trim and door latch repair issues that were not expensive but inconvenient and somewhat painful.
Hope this helps. Not sure my son’s experience was typical.