2001 Dodge Caravan. Is it still safe?

A local courier service has used several Chryco minivans for many years. They have the one with 420K (last time saw it). They have about 25 vehicles, of which at least a dozen are those minivans. I’m pretty sure they wouldn’t keep buying them if they were not reliable. Their larger vans are a mix of Fords and Chevys, but no Dodges.

Friends of mine took off on a 4000 mile vacation trip in a Caravan that had 297K when they left, and over 301K on their return. They traded it a while later for a low mileage one with only 150K which was traded at 220K for their third one. I think it had just over 100K at the time. Obviously they’re not scared of Chryco minivans either.

I am a big fan of their 3.3 and 3.8L V-6s. I think the fans with the 4-cyl engines are under powered.