Other than needing a replacement knuckle, the repairs needed and their cost (presuming that’s P & L) seem within reason. I’m presuming this car was driven fairly aggressively for all of its 130k+ miles, w/ some deferred maintenance issues. Rapid starts, rapid stops, high speed cornering, potholes at speed etc. I’m guessing the knuckle problem is caused by caliper fasteners coming loose, the resultant play eventually damaging the knuckle.
If all that was needed was the suspension, hub, and axle stuff, I’d say go for it. But the most concerning problem is the transmission. I suggest to focus on that problem first. B/c if it can’t be solved, no sense spending money on the other stuff.