Fuse 16 is for the Instrument Cluster and the REM module.. The cluster is part of the PATs system (Passive Antitheft). Because the Cluster is offline, the security handshake cannot be made between the PCM and Cluster, preventing the vehicle from starting.
The REM module controls things like the rear tail lamps, Power sliding doors, rear locks, liftgate, aux climate control. Shut those systems off, replace the fuse, and see if the fuse blows again (without activating those systems).. If ok, activate each system one at time and look to see if and when the fuse blows... If the fuse blows when the rear climate system is engaged, then you know where you need to start looking for shorts. If the fuse blows immediately, then you will need to isolate the REM and Cluster, and retry.
Not sure how deep you want to get with this issue yourself. You will have some disassembly to do to begin isolating the circuits.