Based on visibility alone I would opt for the CRV. The Equinox has poor visibility toward the blind spots, and I the higher beltline made me feel like I was sitting in a bit of a well. Cargo area seems kind of skimpy too. The CRV felt open and airy and has a larger cargo area. The Equinox is probably quieter; Hondas are known for loud road noise on the highway.
Thoroughly test drive each. Seriously. Make the salesmen shut up or stay back at the lot and give a good amount of time to driving them, testing seat comfort, driving position, noise levels.