Replacing the water pump on a Toyota Sienna before it fails?

As a consumer, I think it is prudent to go ahead and replace it. Basically you are paying for the cost of the part to insure that it won’t fail between timing belt intervals. By comparison, I just replaced a water pump on my MPV (has timing chain) at 158K miles. If this were a timing belt engine and if I didn’t replace the water pump at that same time, I would be out double the labor, at a minimum.

Your choice, but understand the risks involved.