You can get some ideas on expected reliablity by picking up a Consomer Reports Car Buyers’ Guide at teh local bookstore.
Comfort is entirely, totally, 100% subjective. I can drive all day in my Scion tC, but a close friend of mine cannot even ride in it. You need to take long test drives. Nobody can tell you what the most comfortable car is for you. You’ll need to find that one out all by yourself.