I have a 2000 Honda CR-V with a door lock problem that's been going on for about a couple months now. What happens is that sometimes the driver's door lock (and only the driver's door) will refuse to unlock. What will happen is all of the other door locks will pop up (meaning the little peg that pops up and down when you lock and unlock the doors) but the driver's door lock will only pop up halfway and the door won't unlock or open.
My dad has already taken the door panel off, cleaned everything out and put it back. It worked fine for about a week and then the lock acted up again. It can't be the key fob because it's brand new and it works fine. And if I put the key in the lock, the door still won't unlock.
Having said all that, when I took the car to get an oil change, my mom mentioned the problem to the mechanic and he somehow got the door to unlock by using the key.